Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly.

ABSTRACT:

Introduction

Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome.

Methods

A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria to healthy bacteria. Analysis of variance/analysis of covariance (ANOVA/ANCOVA), linear discriminant effect-size analyses (LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups.

Results

At genera and species level

SUBMITTER: Kamer AR 

PROVIDER: S-EPMC8040436 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature