ICAM-1 orchestrates the abscopal effect of tumor radiotherapy.

ABSTRACT: Compelling evidence indicates that radiotherapy (RT) has a systemic inhibitory effect on nonirradiated lesions (abscopal effect) in addition to the ablation of irradiated tumors. However, this effect occurs only in rare circumstances in clinical practice, and mechanisms underlying the abscopal effect of RT are neither fully understood nor therapeutically utilized. Here we identified that intercellular adhesion molecule-1 (ICAM-1), an inducible glycoprotein of the immunoglobulin superfamily, is up-regulated in nonirradiated tumors responsive to RT. ICAM-1 expression in preclinical animal models can be noninvasively detected by optical imaging and positron emission tomography (PET) using near-infrared fluorescence dye- and ⁶⁴Cu-labeled imaging probes that we synthesized, respectiv

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC8040592 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature