C-di-AMP, a likely master regulator of bacterial K⁺ homeostasis machinery, activates a K⁺ exporter.

ABSTRACT: bis-(3',5')-cyclic diadenosine monophosphate (c-di-AMP) is a second messenger with roles in virulence, cell wall and biofilm formation, and surveillance of DNA integrity in many bacterial species, including pathogens. Strikingly, it has also been proposed to coordinate the activity of the components of K⁺ homeostasis machinery, inhibiting K⁺ import, and activating K⁺ export. However, there is a lack of quantitative evidence supporting the direct functional impact of c-di-AMP on K⁺ transporters. To gain a detailed understanding of the role of c-di-AMP on the activity of a component of the K⁺ homeostasis machinery in B. subtilis, we have characterized the impact of c-di-AMP on the functional, biochemical, and physiological propert

SUBMITTER: Cereija TB 

PROVIDER: S-EPMC8040634 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature