Presentation and outcome of suspected sepsis in a high-HIV burden, high antiretroviral coverage setting.

ABSTRACT:

Objective

To define sepsis syndromes in high-HIV burden settings in the antiretroviral therapy (ART) era.

Methods

We characterized a prospective cohort of adults presenting to a tertiary emergency department in Harare, Zimbabwe with suspected community-acquired sepsis using blood and urine cultures, urine tuberculosis lipoarabinomannan (TB LAM), and serum cryptococcal antigen (CrAg) testing. The primary outcome was 30-day all-cause mortality.

Results

Of 142 patients enrolled 68% (n=96/142, 95% confidence interval (CI) [60-75%]) were HIV-positive, 41% (n=39/96, 95% CI [31-50%]) of whom were ART-naïve. Among HIV-positive patients, both opportunistic pathogens (TB LAM-positivity, 36%, 95% CI [24-48%]; CrAg-positivity, 15%, 95% CI [7-23%]) and severe non-AIDS infections (

SUBMITTER: Chaka W 

PROVIDER: S-EPMC8040698 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature