Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors.

ABSTRACT: Rationale: The tireless research for effective drug delivery approaches is prompted by poor target tissue penetration and limited selectivity against diseased cells. To overcome these issues, various nano- and micro-carriers have been developed so far, but some of them are characterized by slow degradation time, thus hampering repeated drug administrations. The aim of this study was to pursue a selective delivery of magnetic biodegradable polyelectrolyte capsules in a mouse breast cancer model, using an external magnetic field. Methods: Four different kinds of magnetic polyelectrolyte capsules were fabricated via layer-by-layer assembly of biodegradable polymers on calcium carbonate templates. Magnetite nanoparticles were embedded either into the capsules' shell (sample S) or

SUBMITTER: Svenskaya Y 

PROVIDER: S-EPMC8040826 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature