All or nothing belief updating in patients with schizophrenia reduces precision and flexibility of beliefs.

ABSTRACT: Schizophrenia is characterized by abnormal perceptions and beliefs, but the computational mechanisms through which these abnormalities emerge remain unclear. One prominent hypothesis asserts that such abnormalities result from overly precise representations of prior knowledge, which in turn lead beliefs to become insensitive to feedback. In contrast, another prominent hypothesis asserts that such abnormalities result from a tendency to interpret prediction errors as indicating meaningful change, leading to the assignment of aberrant salience to noisy or misleading information. Here we examine behaviour of patients and control subjects in a behavioural paradigm capable of adjudicating between these competing hypotheses and characterizing belief updates directly on individual trials. We show

SUBMITTER: Nassar MR 

PROVIDER: S-EPMC8041039 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature