Prediction of early recurrence of pancreatic ductal adenocarcinoma after resection.

ABSTRACT:

Background

Even after curative resection, pancreatic ductal adenocarcinoma (PDAC) patients suffer a high rate of recurrence. There is an unmet need to predict which patients will experience early recurrence after resection in order to adjust treatment strategies.

Methods

Data of patients with resectable PDAC undergoing surgical resection between January 2005 and September 2018 were reviewed to stratify for early recurrence defined as occurring within 6 months of resection. Preoperative data including demographics, tumor markers, blood immune-inflammatory factors and clinicopathological data were examined. We employed Elastic Net, a sparse modeling method, to construct models predicting early recurrence using these multiple preoperative factors. As a result, seven preoperativ

SUBMITTER: Sugawara T 

PROVIDER: S-EPMC8041173 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature