External validation and update of prediction models for unfavorable outcomes in hospitalized patients with COVID-19 in Japan.

ABSTRACT:

Introduction

Most of the currently used prognostic models for COVID-19 are based on Western cohorts, but it is unknown whether any are applicable to patients with COVID-19 in Japan.

Methods

This retrospective cohort study included 160 patients with COVID-19 who were admitted to the National Center for Global Health and Medicine between January 26, 2020 and July 25, 2020. We searched PubMed for prognostic models for COVID-19. The predicted outcome was initiation of respiratory support or death. Performance of the candidate models was evaluated according to discrimination and calibration. We recalibrated the intercept of each model with our data. We also updated each model by adding β2-microglobulin (β2MG) to the model and recalculating the intercept and the coefficient of β2M

SUBMITTER: Yamada G 

PROVIDER: S-EPMC8041181 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature