Modeling the circadian regulation of the immune system: Sexually dimorphic effects of shift work.

ABSTRACT: The circadian clock exerts significance influence on the immune system and disruption of circadian rhythms has been linked to inflammatory pathologies. Shift workers often experience circadian misalignment as their irregular work schedules disrupt the natural light-dark cycle, which in turn can cause serious health problems associated with alterations in genetic expressions of clock genes. In particular, shift work is associated with impairment in immune function, and those alterations are sex-specific. The goal of this study is to better understand the mechanisms that explain the weakened immune system in shift workers. To achieve that goal, we have constructed a mathematical model of the mammalian pulmonary circadian clock coupled to an acute inflammation model in the male and female rat

SUBMITTER: Abo SMC 

PROVIDER: S-EPMC8041207 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature