Ontology highlight
ABSTRACT:
SUBMITTER: Drop M
PROVIDER: S-EPMC8041276 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Drop Marcin M Canale Vittorio V Chaumont-Dubel Séverine S Kurczab Rafał R Satała Grzegorz G Bantreil Xavier X Walczak Maria M Koczurkiewicz-Adamczyk Paulina P Latacz Gniewomir G Gwizdak Anna A Krawczyk Martyna M Gołębiowska Joanna J Grychowska Katarzyna K Bojarski Andrzej J AJ Nikiforuk Agnieszka A Subra Gilles G Martinez Jean J Pawłowski Maciej M Popik Piotr P Marin Philippe P Lamaty Frédéric F Zajdel Paweł P
ACS chemical neuroscience 20210311 7
Serotonin type 6 receptor (5-HT<sub>6</sub>R) has gained particular interest as a promising target for treating cognitive deficits, given the positive effects of its antagonists in a wide range of memory impairment paradigms. Herein, we report on degradation of the 1<i>H</i>-pyrrolo[3,2-<i>c</i>]quinoline scaffold to provide the 2-phenyl-1<i>H</i>-pyrrole-3-carboxamide, which is devoid of canonical indole-like skeleton and retains recognition of 5-HT<sub>6</sub>R. This modification has changed t ...[more]