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A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles.

ABSTRACT: 3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol.

SUBMITTER: Garcia-Vazquez V

PROVIDER: S-EPMC8041373 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles.

García-Vázquez Víctor V Hoteite Larry L Lakeland Christopher P CP Watson David W DW Harrity Joseph P A JPA

Organic letters 20210324 7

3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol. ...[more]

PMID: 33759534

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