Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Dogs.

ABSTRACT: Colon absorption is a key determinant for the successful development of modified-release (MR) formulations, and the risk that colon absorption may limit the in vivo performance of an MR product can be assessed early by various in vitro tests or by preclinical in vivo regional absorption studies in dogs. Mechanistic physiologically based biopharmaceutics modeling (PBBM) is becoming increasingly accepted to predict in vivo performance and guide formulation development; however, no evaluation of the ability to predict colon absorption has been performed. The purpose of this study was to investigate if regional and colon absorption of drugs in dogs could be predicted with sufficient accuracy using PBBM to enable the replacement of in vivo dog studies in the early assessment of colon absorption

SUBMITTER: Eckernas E 

PROVIDER: S-EPMC8041381 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature