Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition.

ABSTRACT:

Background

Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. So far, many environmental chemicals, including drug candidates, food additives, and industrial chemicals, have not been thoroughly evaluated for their inhibitory effects on AChE activity. AChE inhibitors can have therapeutic applications (e.g., tacrine and donepezil) or neurotoxic consequences (e.g., insecticides and nerve agents).

Objectives

The objective of the current study was to identify environmental chemicals that inhibit AChE activity using in vitro and in silico models.

Methods

To identify AChE inhibitors rapidly and efficien

SUBMITTER: Li S 

PROVIDER: S-EPMC8041433 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature