Chronic Exposure to Cadmium Induces Differential Methylation in Mice Spermatozoa.

ABSTRACT: Cadmium exposure is ubiquitous and has been linked to diseases including cancers and reproductive defects. Since cadmium is nonmutagenic, it is thought to exert its gene dysregulatory effects through epigenetic reprogramming. Several studies have implicated germline exposure to cadmium in developmental reprogramming. However, most of these studies have focused on maternal exposure, while the impact on sperm fertility and disease susceptibility has received less attention. In this study, we used reduced representation bisulfite sequencing to comprehensively investigate the impact of chronic cadmium exposure on mouse spermatozoa DNA methylation. Adult male C57BL/J6 mice were provided water with or without cadmium chloride for 9 weeks. Sperm, testes, liver, and kidney tissues were collected a

SUBMITTER: Saintilnord WN 

PROVIDER: S-EPMC8041459 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature