Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth.

ABSTRACT: A minor subset of individuals infected with HIV-1 develop antibody neutralization breadth during the natural course of the infection, often linked to chronic, high-level viremia. Despite significant efforts, vaccination strategies have been unable to induce similar neutralization breadth and the mechanisms underlying neutralizing antibody induction remain largely elusive. Broadly neutralizing antibody responses can also be found in individuals who control HIV to low and even undetectable plasma levels in the absence of antiretroviral therapy, suggesting that high antigen exposure is not a strict requirement for neutralization breadth. We therefore performed an analysis of paired heavy and light chain B-cell receptor (BCR) repertoires in 12,591 HIV-1 envelope-specific single memory B-cells

SUBMITTER: Cizmeci D 

PROVIDER: S-EPMC8041465 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature