Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.

ABSTRACT:

Introduction

Analyses of cerebrospinal fluid (CSF) metabolites in large, healthy samples have been limited and potential demographic moderators of brain metabolism are largely unknown.

Objective

Our objective in this study was to examine sex and race differences in 33 CSF metabolites within a sample of 129 healthy individuals (37 African American women, 29 white women, 38 African American men, and 25 white men).

Methods

CSF metabolites were measured with a targeted electrochemistry-based metabolomics platform. Sex and race differences were quantified with both univariate and multivariate analyses. Type I error was controlled for by using a Bonferroni adjustment (0.05/33 = .0015).

Results

Multivariate Canonical Variate Analysis (CVA) of the 33 metabolites showed

SUBMITTER: Reavis ZW 

PROVIDER: S-EPMC8041469 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature