KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3.

ABSTRACT: Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus‑end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Notably, KIF4A plays important roles in tumor growth and progression, and its expression is associated with the prognosis of several types of cancer. However, the potential role and molecular mechanisms of KIF4A in bladder cancer development remain unclear. The present study demonstrate

SUBMITTER: Zheng P 

PROVIDER: S-EPMC8041479 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature