Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network.

ABSTRACT:

Background & aims

Ashwagandha (Withania somnifera) is widely used in Indian Ayurvedic medicine. Several dietary supplements containing ashwagandha are marketed in the US and Europe, but only one case of drug-induced liver injury (DILI) due to ashwagandha has been published. The aim of this case series was to describe the clinical phenotype of suspected ashwagandha-induced liver injury.

Methods

Five cases of liver injury attributed to ashwagandha-containing supplements were identified; three were collected in Iceland during 2017-2018 and two from the Drug-Induced Liver Injury Network (DILIN) in 2016. Other causes for liver injury were excluded. Causality was assessed using the DILIN structured expert opinion causality approach.

Results

Among the five patients, three we

SUBMITTER: Bjornsson HK 

PROVIDER: S-EPMC8041491 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature