Brain metabolic changes across King's stages in amyotrophic lateral sclerosis: a ¹⁸F-2-fluoro-2-deoxy-D-glucose-positron emission tomography study.

ABSTRACT:

Purpose

To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King's staging system, using brain ¹⁸F-2-fluoro-2-deoxy-D-glucose-PET (¹⁸F-FDG-PET).

Methods

Three hundred ninety ALS cases with King's stages 1, 2, and 3 (n = 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain ¹⁸F-FDG-PET at diagnosis. King's stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King's 1, King's 2, King's 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET an

SUBMITTER: Canosa A 

PROVIDER: S-EPMC8041703 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature