Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.

ABSTRACT: COVID-19, the infectious disease caused by the most recently discovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global pandemic. It dramatically affects people's health and daily life. Neurological complications are increasingly documented for patients with COVID-19. However, the effect of COVID-19 on the brain is less studied, and existing quantitative neuroimaging analyses of COVID-19 were mainly based on the univariate voxel-based morphometry analysis (VBM) that requires corrections for a large number of tests for statistical significance, multivariate approaches that can reduce the number of tests to be corrected have not been applied to study COVID-19 effect on the brain yet. In this study, we leveraged source-based morphometry (SBM) analysis, a mult

SUBMITTER: Duan K 

PROVIDER: S-EPMC8041745 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature