Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients.

ABSTRACT: Postoperative delirium (POD) represents a confusional state during days/weeks after surgery and is particularly frequent in elderly patients. Hardly any fMRI studies were conducted to understand the underlying pathophysiology of POD patients. This prospective observational cohort study aims to examine changes of specific resting-state functional connectivity networks across different time points (pre- and 3-5 months postoperatively) in delirious patients compared to no-POD patients. Two-hundred eighty-three elderly surgical patients underwent preoperative resting-state fMRI (46 POD). One-hundred seventy-eight patients completed postoperative scans (19 POD). For functional connectivity analyses, three functional connectivity networks with seeds located in the orbitofrontal cortex (OFC), nuc

SUBMITTER: Winterer JM 

PROVIDER: S-EPMC8041755 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature