An acute phase protein α₁-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action.

ABSTRACT: The molecular mechanism for acute kidney injury (AKI) and its progression to chronic kidney disease (CKD) continues to be unclear. In this study, we investigated the pathophysiological role of the acute phase protein α₁-acid glycoprotein (AGP) in AKI and its progression to CKD using AGP KO mice. Plasma AGP levels in WT mice were increased by about 3.5-fold on day 1-2 after renal ischemia-reperfusion (IR), and these values then gradually decreased to the level before renal IR on day 7-14. On day 1 after renal IR, the AGP KO showed higher renal dysfunction, tubular injury and renal inflammation as compared with WT. On day 14, renal function, tubular injury and renal inflammation in WT had recovered, but the recovery was delayed, and renal fibrosis continued to progress in AGP KO.

SUBMITTER: Watanabe H 

PROVIDER: S-EPMC8041882 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature