Angiogenesis imaging study using interim [¹⁸F] RGD-K5 PET/CT in patients with lymphoma undergoing chemotherapy: preliminary evidence.

ABSTRACT:

Background

Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [¹⁸F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography-computed tomography (PET) on patients presenting with lymphoma. Nineteen patients at Rouen's Henri Becquerel Cancer Centre were prospectively included. Fluorodeoxyglucose (FDG) and RGD-K5 PET were performed before (C0) and after (C2) two cycles of chemotherapy. End-of-treatment FDG PET was performed for final evaluation. Maximum standardised uptake value (SUVmax), SUVmean, Metabolic Tumour Volume (MTV) and Angiogenic Tumour Volume (ATV) were measured for all lesions. RGD SUVmax and SUVmean were also analysed in 13 normal organs at C0 and C2. The patient's treatment response was co

SUBMITTER: Tonnelet D 

PROVIDER: S-EPMC8041962 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature