Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality.

ABSTRACT: Absorption of dietary phosphate (Pi) across intestinal epithelia is a regulated process mediated by transcellular and paracellular pathways. Although hyperphosphatemia is a risk factor for the development of cardiovascular disease, the amount of ingested Pi in a typical Western diet is above physiological needs. While blocking intestinal absorption has been suggested as a therapeutic approach to prevent hyperphosphatemia, a complete picture regarding the identity and regulation of the mechanism(s) responsible for intestinal absorption of Pi is missing. The Na⁺/Pi cotransporter NaPi-IIb is a secondary active transporter encoded by the Slc34a2 gene. This transporter has a wide tissue distribution and within the intestinal tract is located at the apical membrane of epithelial cells

SUBMITTER: Pastor-Arroyo EM 

PROVIDER: S-EPMC8042035 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature