Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis.
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ABSTRACT:
SUBMITTER: Fan T
PROVIDER: S-EPMC8042068 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis.
Fan Tongqiang T Huang Youjun Y
Scientific reports 20210412 1
This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis. We made a comprehensively joint-research of chromatin accessibility of five species during embryogenesis by integration of ATAC-seq and RNA-seq datasets. Regulatory roles of candidate early embryonic TFs were investigated. Widespread accessible chromatin in early embryos overlapped with p ...[more]
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