Modularization of grid cells constrained by the pyramidal patch lattice.

ABSTRACT: Grid cells provide a metric representation of self-location. They are organized into modules, showing discretized scales of grid spacing, but the underlying mechanism remains elusive. In this modeling study, we propose that the hexagonal lattice of pyramidal cell patches may underlie the discretization of grid spacing and orientation. In the continuous attractor network composed of interneurons, stellate and pyramidal cells, the hexagonal lattice of bump attractors is specifically aligned to the patch lattice under 22 conditions determined by the geometry of the patch lattice, while pyramidal cells exhibit synchrony to diverse extents. Given the bump attractor lattice in each module originates from those 22 scenarios, the experimental data on the grid spacing ratio and orientation differen

SUBMITTER: Wang T 

PROVIDER: S-EPMC8042349 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature