Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.

ABSTRACT: The Stimulator of Interferon Genes (STING) pathway is implicated in the innate immune response and is important in both oncogenesis and cancer treatment. Specifically, activation of the cytosolic DNA sensor STING in antigen-presenting cells (APCs) induces a type I interferon response and cytokine production that facilitates antitumor immune therapy. However, use of STING agonists (STINGa) as a cancer therapeutic has been limited by unfavorable pharmacological properties and targeting inefficiency due to rapid clearance and limited uptake into the cytosol. Exosomes, a class of extracellular vesicles shed by all cells are under consideration for their use as effective carriers of drugs owing to their innate ability to be taken up by cells and their biocompatibility for optimal drug biodistri

SUBMITTER: McAndrews KM 

PROVIDER: S-EPMC8042450 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature