Confirmed disability progression provides limited predictive information regarding future disease progression in multiple sclerosis.

ABSTRACT:

Background

Although confirmed disability progression (CDP) is a common outcome in multiple sclerosis (MS) clinical trials, its predictive value for long-term outcomes is uncertain.

Objective

To investigate whether CDP at month 24 predicts subsequent disability accumulation in MS.

Methods

The Comprehensive Longitudinal Investigation of Multiple Sclerosis at Brigham and Women's Hospital includes participants with relapsing-remitting MS or clinically isolated syndrome with Expanded Disability Status Scale (EDSS) scores ≤5 (N = 1214). CDP was assessed as a predictor of time to EDSS score 6 (EDSS 6) and to secondary progressive MS (SPMS) using a Cox proportional hazards model; adjusted models included additional clinical/participant characteristics. Models were compared us

SUBMITTER: Healy BC 

PROVIDER: S-EPMC8042549 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature