Alterations in the human oral and gut microbiomes and lipidomics in COVID-19.

ABSTRACT:

Objective

To characterise the oral microbiome, gut microbiome and serum lipid profiles in patients with active COVID-19 and recovered patients; evaluate the potential of the microbiome as a non-invasive biomarker for COVID-19; and explore correlations between the microbiome and lipid profile.

Design

We collected and sequenced 392 tongue-coating samples, 172 faecal samples and 155 serum samples from Central China and East China. We characterised microbiome and lipid molecules, constructed microbial classifiers in discovery cohort and verified their diagnostic potential in 74 confirmed patients (CPs) from East China and 37 suspected patients (SPs) with IgG positivity.

Results

Oral and faecal microbial diversity was significantly decreased in CPs versus healthy controls

SUBMITTER: Ren Z 

PROVIDER: S-EPMC8042598 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature