Comparative regulomics supports pervasive selection on gene dosage following whole genome duplication.

ABSTRACT:

Background

Whole genome duplication (WGD) events have played a major role in eukaryotic genome evolution, but the consequence of these extreme events in adaptive genome evolution is still not well understood. To address this knowledge gap, we used a comparative phylogenetic model and transcriptomic data from seven species to infer selection on gene expression in duplicated genes (ohnologs) following the salmonid WGD 80-100 million years ago.

Results

We find rare cases of tissue-specific expression evolution but pervasive expression evolution affecting many tissues, reflecting strong selection on maintenance of genome stability following genome doubling. Ohnolog expression levels have evolved mostly asymmetrically, by diverting one ohnolog copy down a path towards lower expre

SUBMITTER: Gillard GB 

PROVIDER: S-EPMC8042706 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature