Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study.

ABSTRACT:

Background

Metformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we stop treatment. We compared the effects of metformin withdrawal after long-term (LT) and short term (ST) treatment in PCOS women that had previously well responded to metformin.

Methods

We conducted observational longitudinal study including 44 PCOS women (31 (28-36) years and BMI 32.5 (27.7-34.9) kg/m²) that were followed for 6 months after metformin withdrawal. Prior inclusion, ST group had been treated with metformin on average for 1.03 ± 0.13 year, LT group for 5.07 ± 2.52 years. We followed anthropometric, metabolic, reproductive parameters and

SUBMITTER: Kravos NA 

PROVIDER: S-EPMC8042848 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature