Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.

ABSTRACT:

Background

Evaluation of genetic relatedness of malaria parasites is a useful tool for understanding transmission patterns, but patterns are not easily detectable in areas with moderate to high malaria transmission. To evaluate the feasibility of detecting genetic relatedness in a moderate malaria transmission setting, relatedness of Plasmodium falciparum infections was measured in cohort participants from randomly selected households in the Kihihi sub-county of Uganda (annual entomological inoculation rate of 27 infectious bites per person).

Methods

All infections detected via microscopy or Plasmodium-specific loop mediated isothermal amplification from passive and active case detection during August 2011-March 2012 were genotyped at 26 microsatellite loci, providing data f

SUBMITTER: Briggs J 

PROVIDER: S-EPMC8042884 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature