Methamphetamine-induced changes in myocardial gene transcription are sex-dependent.

ABSTRACT:

Background

Prior work demonstrated that female rats (but not their male littermates) exposed to methamphetamine become hypersensitive to myocardial ischemic injury. Importantly, this sex-dependent effect persists following 30 days of subsequent abstinence from the drug, suggesting that it may be mediated by long term changes in gene expression that are not rapidly reversed following discontinuation of methamphetamine use. The goal of the present study was to determine whether methamphetamine induces sex-dependent changes in myocardial gene expression and whether these changes persist following subsequent abstinence from methamphetamine.

Results

Methamphetamine induced changes in the myocardial transcriptome were significantly greater in female hearts than male hearts both in

SUBMITTER: Chavva H 

PROVIDER: S-EPMC8042975 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature