Comprehensive analysis of lumbar disc degeneration and autophagy-related candidate genes, pathways, and targeting drugs.

ABSTRACT:

Background

Lumbar disc degeneration (LDD) is an essential pathological mechanism related to low back pain. Current research on spinal surgery focused on the sophisticated mechanisms involved in LDD, and autophagy was regarded as an essential factor in the pathogenesis.

Objectives

Our research aimed to apply a bioinformatics approach to select some candidate genes and signaling pathways in relationship with autophagy and LDD and to figure out potential agents targeting autophagy- and LDD-related genes.

Materials and methods

Text mining was used to find autophagy- and LDD-related genes. The DAVID program was applied in Gene Ontology and pathway analysis after selecting these genes. Several important gene modules were obtained by establishing a network of protein-protein

SUBMITTER: Xu WL 

PROVIDER: S-EPMC8043061 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature