Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine.

ABSTRACT:

Background

Selenium (Se) is a nutritionally essential trace element and health may be improved by increased Se intake. Previous kinetic studies have shown differences in metabolism of organic vs. inorganic forms of Se [e.g., higher absorption of selenomethionine (SeMet) than selenite (Sel), and more recycling of Se from SeMet than Sel]. However, the effects on Se metabolism after prolonged Se supplementation are not known.

Objective

To determine how the metabolism and transport of Se changes in the whole-body in response to Se-supplementation by measuring Se kinetics before and after 2 years of Se supplementation with SeMet.

Methods

We compared Se kinetics in humans [n = 31, aged 40 ± 3 y (mean ± SEM)] studied twice after oral tracer administration; initially (

SUBMITTER: Patterson BH 

PROVIDER: S-EPMC8043082 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature