Lubricin in experimental and naturally occurring osteoarthritis: a systematic review.

ABSTRACT:

Objective

Lubricin is increasingly being evaluated as an outcome measure in studies investigating post-traumatic and naturally occurring osteoarthritis. However, there are discrepancies in results, making it unclear as to whether lubricin is increased, decreased or unchanged in osteoarthritis. The purpose of this study was to review all papers that measured lubricin in joint injury or osteoarthritis in order to draw conclusions about lubricin regulation in joint disease.

Design

A systematic search of the Pubmed, Web of Knowledge, and EBSCOhost databases for papers was performed. Inclusion criteria were in vivo studies that measured lubricin in humans or animals with joint injury, that investigated lubricin supplementation in osteoarthritic joints, or that described the pheno

SUBMITTER: Watkins AR 

PROVIDER: S-EPMC8043104 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature