Local and Systemic Antitumor Effects of Photo-activatable Paclitaxel Prodrug on Rat Breast Tumor Models.

ABSTRACT: We demonstrated that a large primary and a small untreated distant breast cancer could be controlled by local treatment with our light-activatable paclitaxel (PTX) prodrug. We hypothesized that the treated tumor would be damaged by the combinational effects of photodynamic therapy (PDT) and locally released PTX and that the distant tumor would be suppressed by systemic antitumor effects. Syngeneic rat breast cancer models (single- and two-tumor models) were established on Fischer 344 rats by subcutaneous injection of MAT B III cells. The rats were injected with PTX prodrug (dose: 1 umole kg^-1 , i.v.), and tumors were treated with illumination using a 690-nm laser (75 or 140 mW cm^-1 for 30 min, cylindrical light diffuser, drug-light interval [DLI] 9 h). Larger tumors (

SUBMITTER: Subramaniyan B 

PROVIDER: S-EPMC8043141 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature