Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines.

ABSTRACT: The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1Ψ) to increase their effectiveness. In this Outlook, we summarize the development and function of m1Ψ in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.

SUBMITTER: Nance KD 

PROVIDER: S-EPMC8043204 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature