Sex effects in the association between airway microbiome and asthma.

ABSTRACT:

Background

Sex differences exist in asthma susceptibility and severity. Accumulating evidence has linked airway microbiome dysbiosis to asthma, and airway microbial communities have been found to differ by sex. However, whether sex modifies the link between airway microbiome and asthma has not been investigated.

Objective

To evaluate sex effects in the association between airway microbiome and asthma.

Methods

We analyzed induced sputum samples from 47 subjects (n = 23 patients with asthma and n = 24 normal controls) using 16S ribosomal RNA gene sequencing methods. The bacterial composition was analyzed for sex differences. Bacterial associations with asthma were assessed for each sex at the core taxa and genus levels.

Results

The microbiome in induced sputum di

SUBMITTER: Chen R 

PROVIDER: S-EPMC8043253 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature