Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration.

ABSTRACT: Cells actively position their nuclei within the cytoplasm for multiple cellular and physiological functions.^1-3 Consequently, nuclear mispositioning is usually associated with cell dysfunction and disease, from muscular disorders to cancer metastasis.^4-7 Different cell types position their nuclei away from the leading edge during cell migration.^8-11 In migrating fibroblasts, nuclear positioning is driven by an actin retrograde flow originated at the leading edge that drives dorsal actin cables away from the leading edge. The dorsal actin cables connect to the nuclear envelope by the linker of nucleoskeleton and cytoskeleton (LINC) complex on transmembrane actin-associated nuclear (TAN) lines.^12-14 Dorsal actin cables are required for the formatio

SUBMITTER: Calero-Cuenca FJ 

PROVIDER: S-EPMC8043254 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature