Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia.

ABSTRACT:

Background

Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in community-acquired pneumonia and hypothesized that infection-induced changes in these potential biomarkers differ between groups of pathogens and could predict microbial etiology.

Methods

Blood samples from a prospective cohort of 267 patients with community-acquired pneumonia were analyzed for hepcidin, ferritin, iron, transferrin, and soluble transferrin receptor at admission, clinical stabilization, and a 6-week follow-up. A total of 111 patients with an established microbiological diagnosis confined to 1 microbial group (atypical bacterial, typical bacteri

SUBMITTER: Oppen K 

PROVIDER: S-EPMC8043258 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature