Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature.

ABSTRACT: Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, transcriptional analysis of patient lesions identified an interferon stimulated gene (ISG) signature. To determine whether localized L. braziliensis infection triggers a systemic immune response that may influence the disease, we performed RNA sequencing (RNA-seq) on the blood of L. braziliensis-infected patients and healthy controls. Functional enrichment analysis identified an ISG signature as the dominant transcriptional response in the blood of patients. This ISG signature was associated with an increase in

SUBMITTER: Farias Amorim C 

PROVIDER: S-EPMC8043375 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature