Signatures of COVID-19 severity and immune response in the respiratory tract microbiome.

ABSTRACT: Viral infection of the respiratory tract can be associated with propagating effects on the airway microbiome, and microbiome dysbiosis may influence viral disease. To define the respiratory tract microbiome in COVID-19 and relationship disease severity, systemic immunologic features, and outcomes. We examined 507 oropharyngeal, nasopharyngeal and endotracheal samples from 83 hospitalized COVID-19 patients, along with non-COVID patients and healthy controls. Bacterial communities were interrogated using 16S rRNA gene sequencing, commensal DNA viruses Anelloviridae and Redondoviridae were quantified by qPCR, and immune features were characterized by lymphocyte/neutrophil (L/N) ratios and deep immune profiling of peripheral blood mononuclear cells (PBMC). COVID-19 patients had upper respirato

SUBMITTER: Merenstein C 

PROVIDER: S-EPMC8043476 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature