Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis.

ABSTRACT: Meningitis is a potentially life-threatening infection characterized by the inflammation of the leptomeningeal membranes. Many different viral and bacterial pathogens can cause meningitis, with differences in mortality rates, risk of developing neurological sequelae, and treatment options. Here, we constructed a compendium of digital cerebrospinal fluid (CSF) proteome maps to define pathogen-specific host response patterns in meningitis. The results revealed a drastic and pathogen-type specific influx of tissue-, cell-, and plasma proteins in the CSF, where, in particular, a large increase of neutrophil-derived proteins in the CSF correlated with acute bacterial meningitis. Additionally, both acute bacterial and viral meningitis result in marked reduction of brain-enriched proteins. Genera

SUBMITTER: Bakochi A 

PROVIDER: S-EPMC8043743 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature