Reduction in acute kidney injury post cardiac surgery using balanced forced diuresis: a randomized, controlled trial.

ABSTRACT:

Objectives

Our goal was to investigate the efficacy of balanced forced diuresis in reducing the rate of acute kidney injury (AKI) in cardiac surgical patients requiring cardiopulmonary bypass (CPB), using the RenalGuard® (RG) system.

Methods

Patients at risk of developing AKI (history of diabetes and/or anaemia; estimated glomerular filtration rate 20-60 ml/min/1.73 m2; anticipated CPB time >120 min; log EuroSCORE > 5) were randomized to the RG system group (n = 110) or managed according to current practice (control = 110). The primary end point was the development of AKI within the first 3 postoperative days as defined by the RIFLE (Risk, Injury, Failure, Loss of kidney function, End-stage renal disease) criteria.

Results

There were no significant differences in preo

SUBMITTER: Luckraz H 

PROVIDER: S-EPMC8043764 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature