Addition of HER2 and CD44 to ¹⁸F-FDG PET-based clinico-radiomic models enhances prediction of neoadjuvant chemoradiotherapy response in esophageal cancer.

ABSTRACT:

Objectives

To assess the complementary value of human epidermal growth factor receptor 2 (HER2)-related biological tumor markers to clinico-radiomic models in predicting complete response to neoadjuvant chemoradiotherapy (NCRT) in esophageal cancer patients.

Methods

Expression of HER2 was assessed by immunohistochemistry in pre-treatment tumor biopsies of 96 patients with locally advanced esophageal cancer. Five other potentially active HER2-related biological tumor markers in esophageal cancer were examined in a sub-analysis on 43 patients. Patients received at least four of the five cycles of chemotherapy and full radiotherapy regimen followed by esophagectomy. Three reference clinico-radiomic models based on ¹⁸F-FDG PET were constructed to predict pathologic re

SUBMITTER: Beukinga RJ 

PROVIDER: S-EPMC8043921 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature