Mechanical Reperfusion Following Prolonged Global Cerebral Ischemia Attenuates Brain Injury.

ABSTRACT: Previous experiments demonstrated improved outcome following prolonged cerebral ischemia given controlled brain reperfusion using extracorporeal circulation. The current study further investigates this. Young adult pigs were exposed to 30 min of global normothermic cerebral ischemia, achieved through intrathoracic clamping of cerebral arteries, followed by 20 min of isolated mechanical brain reperfusion. Leukocyte-filtered blood was delivered by a roller-pump at fixed pressure and flow. One experimental group additionally had a custom-made buffer solution delivered at 1:8 ratio with the blood. Hemodynamics including intracranial pressure were monitored. Blood gases were from peripheral arteries and the sagittal sinus, and intraparenchymal brain microdialysis was performed. The brains were

SUBMITTER: Lindblom RPF 

PROVIDER: S-EPMC8043930 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature