Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease.

ABSTRACT:

Background

Olfactory impairment is evident in Alzheimer's disease (AD); however, its precise relationships with clinical biomarker measures of tau pathology and neuroinflammation are not well understood.

Objective

To determine if odor identification performance measured with the University of Pennsylvania Smell Identification Test (UPSIT) is related to in vivo measures of tau pathology and neuroinflammation.

Methods

Cognitively normal and cognitively impaired participants were selected from an established research cohort of adults aged 50 and older who underwent neuropsychological testing, brain MRI, and amyloid PET. Fifty-four participants were administered the UPSIT. Forty-one underwent 18F-MK-6240 PET (measuring tau pathology) and fifty-three underwent 11C-PBR28 PE

SUBMITTER: Klein J 

PROVIDER: S-EPMC8044007 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature