Differential biomechanical responses of elastic and muscular arteries to angiotensin II-induced hypertension.

ABSTRACT: Elastic and muscular arteries are distinguished by their distinct microstructures, biomechanical properties, and smooth muscle cell contractile functions. They also exhibit differential remodeling in aging and hypertension. Although regional differences in biomechanical properties have been compared, few studies have quantified biaxial differences in response to hypertension. Here, we contrast passive and active changes in large elastic and medium- and small-sized muscular arteries in adult mice in response to chronic infusion of angiotensin over 14 days. We found a significant increase in wall thickness, both medial and adventitial, in the descending thoracic aorta that associated with trends of an increased collagen:elastin ratio. There was adventitial thickening in the small-sized mesen

SUBMITTER: Murtada SI 

PROVIDER: S-EPMC8044024 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature