Ontology highlight
ABSTRACT:
SUBMITTER: Narendran S
PROVIDER: S-EPMC8044134 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Narendran Siddharth S Pereira Felipe F Yerramothu Praveen P Apicella Ivana I Wang Shao-Bin SB Ambati Kameshwari K Hirahara Shuichiro S Kim Younghee Y Ambati Meenakshi M Ambati Vidya L VL Huang Peirong P Varshney Akhil A Nagasaka Yosuke Y Fukuda Shinichi S Baker Kirstie L KL Marion Kenneth M KM Deussing Jan M JM Sadda Srinivas R SR Gelfand Bradley D BD Ambati Jayakrishna J
Signal transduction and targeted therapy 20210414 1
Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We report that AβOs induce RPE degeneration, a clinical hallmark of geographic atrophy (GA), a vision-threatening late stage of AMD that is currently untreatable. We demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that R ...[more]